How Long Do Polynucleotides Take to Work?
The polynucleotides got incredibly popular due to their ability to hydrate the skin, stimulate collagen and improve elasticity, and heal the skin from within.
They’re considered better than Botox and fillers as they work from within the skin by triggering the skin cells to grow, improve, and repair. However, one question that every person has is, How long do polynucleotides take to work?
They show the gradual results for hydrating your skin and improving the radiance, usually 1 to 2 weeks for the initial results. Visible improvements in elasticity and fine lines appear within 4 to 6 weeks.
Full results, making your skin look younger, fresher, and brighter, appear within 8 to 12 weeks. Let’s learn more about the polynucleotides, how they work, and what the potential benefits and side effects are.
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What Are Polynucleotides?
Polynucleotides are the fragments of the DNA of the Salmon fish that are properly purified to be used in humans.
Salmon DNA is highly compatible with human DNA, and has properties in it that can help the human skin to heal and improve from within, fixing the sagging eye, dark circles, fine lines or the frown lines due to ageing, medical conditions or allergies.
The polynucleotides are first taken from the Salmon fish, purified, and made safe for humans, and then available in the form of injections, gels, and creams. The most used form is the injection, in which the polynucleotides are injected into your body.
They repair and hydrate the skin, improving elasticity, firmness, and also fix the ageing signs on it by boosting the collagen.

How Long Do Polynucleotides Take to Work?
Unlike fillers or Botox, which offer quick results, polynucleotides take time to work. It’s because they boost the natural abilities of your body, such as the collagen, growth cells, which work together to hydrate your skin, improve it, and heal from within.
The initial results start to appear in 1 to 2 weeks when you notice improved radiance and hydration in your skin.
Then, after 4 to 6 weeks, you see visible results in the firmness and the elasticity of your skin when you feel your skin being stronger and tighter.
After 8 to 12 weeks, you’ll see the best results from polynucleotides, with brighter, fresher, and more youthful skin.
How Do Polynucleotides Work?
When the polynucleotides are injected into your body, within a few days, they bind with the water molecules of the body, keeping the skin moist for long periods.
They power up the fibroblasts, which are the cells that make the collagen and the elastin, making your skin gradually firmer, brighter and younger looking.
If you have damaged areas on your skin, such as acne scars, sunburn or stretch marks, then the polynucleotides help the body to recover faster.
Furthermore, these fragments also calm down the inflamed or sensitive skin and also slow down the skin cell death, so the skin stays youthful-looking for a longer period.
How Long Do Polynucleotides Last?
How long the results last totally depends on the person’s skin. For some, they may last longer, while for others, they may start to fade a little faster.
However, usually, the results last from 6 to 12 months, which is way more long-lasting than other skin treatments.
The best thing about this aesthetic treatment is that you can always top it up before the results start to fade. To maintain the best results, make sure you get the treatment again after 3 to 6 months.
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Benefits and Potential Side Effects of Polynucleotides
Before you take this treatment for your skin, make sure you know about its benefits and the potential side effects.

Benefits
These are the advantages of polynucleotides.
- Collagen boost: This treatment activates the collagen, making your skin bouncy and firmer.
- Even skin tone: It smooths your skin for a brighter, smoother look.
- Reduce fine lines: It significantly reduces the fine lines that make your skin look younger and softer.
Side Effects
These are the potential side effects of polynucleotides.

- Redness: After the surgery, your skin may become red.
- Swelling: You may also get mild puffiness and swelling
- Allergic reactions: They’re rare but can happen
- Lumps: You may also feel some small bumps on your skin post-treatment.
- Itchiness: Itchiness is also common but lasts for a short period.
- Bruising: Minor bruising is common but heals quickly.

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How long do polynucleotides take to work? They work a little slower than other aesthetic treatments. The initial results usually show up in the first 1 to 2 weeks when you feel your skin is fresher and softer. In 4 to 6 weeks, the elasticity and firmness of your skin will improve.
The final results of the polynucleotides appear in 8 to 12 weeks, when your skin is more vibrant, tighter, firmer, bouncy, and soft. You may need top-up treatments every 3 to 6 months to maintain optimal results.
If you have sagging eyelids, under-eye dark circles, loose skin, or excess fat around your eyes, then contact Asli Tarcan Clinic for the advanced blepharoplasty and brow lift surgeries.

This article is medically reviewed by Ophthalmologist Dr. Mehmet
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How long does it take to see results from polynucleotide treatment?
Your skin gets fresher and more hydrated in 1 to 2 weeks. The elasticity and firmness improve within 4 to 6 weeks, and the best results that make your skin bouncy, vibrant, and tighter show up in 8 to 12 weeks.
What is the timeline for polynucleotides?
The results take around 1 to 2 weeks for your skin to feel softer and more hydrated, 4 to 6 weeks for firmness and elasticity improvement, and full results in 8 to 12 weeks.
Are 2 sessions of polynucleotides enough?
It depends on the condition of your skin. Usually, you get the best results in 2 to 3 sessions.
